Job Description
Job Description: Consultant, Chemistry
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Location: Remote
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Company: OS Therapeutics Inc., a Delaware corporation (“OS Tx”)
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Application Process
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To apply, please submit your resume and a brief cover letter outlining your qualifications and interest in the role to hiring@ostherapeutics.com.
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About OS Tx
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OS Therapeutics is a fast-growing US biotech company build around a mission to make the impossible possible for patients facing difficult-to-treat diseases. We are pioneering next-generation therapeutics that turn breakthrough science into life-changing therapies. That vision is built on a validated scientific platform, a focused strategy with a clear development roadmap, and a team with a track record of disciplined execution. Together, they position us toward a bold ambition: bringing transformative medicines to the patients and improving lives with speed and scientific discipline.
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Position Overview
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OS Therapeutics is seeking a Chemistry Consultant (part-time) with industry experience in siRNA therapeutics to support our discovery and preclinical development efforts, working closely with the leadership team. Operating in a lean, fast-paced startup environment, the consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development. This is a high-impact advisory engagement for an experienced oligonucleotide chemist who enjoys translating chemistry insights into differentiated drug candidates.
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Key Responsibilities
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· Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
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· Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
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· Advise on candidate selection and development, including developability and readiness for preclinical studies.
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· Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.
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Qualifications
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· PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)
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· Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
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· Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and delivery.
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· Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.
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Desired Attributes
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· Hands-on, pragmatic, and resourceful—comfortable rolling up sleeves and executing.
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· Strong interpersonal skills and the ability to build trust across scientific, operational, and partner ecosystems.
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· High personal integrity and ability to handle confidential information with discretion.
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Why Join OS Tx?
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· Opportunity to shape and build a pioneering biotech company at a formative stage.
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· Collaborative and innovative culture with direct exposure to scientific and corporate decision-making.
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· Meaningful career growth opportunities as the company scales toward clinical development.
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· Competitive compensation and benefits package (details below).
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OS Tx is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.